The Program for International Student Assessment (PISA) was developed by the Organization for Economic Cooperation and Development to measure students’ knowledge and skills needed for today’s society. PISA is a large-scale assessment of 15-year-old students in reading, mathematics, and science. In this analysis of PISA data from Bosnia and Herzegovina (BIH), we examined the relationship between gender, mathematics achievement, and perceived meaning in life in BIH students. The sample for this analysis comprised 6480 students (3148 females and 3332 males). The results of the analysis revealed a small but statistically significant, negative relationship between mathematics and the student’s perception of the meaning in life. Boys achieved higher scores in mathematics than girls, but the difference was relatively small. In addition, boys’ rating of meaning in life was higher than that of girls. Knowing what factors influence mathematical achievement might help educators create better intervention programs. In conclusion, we provided some possible explanations for these data.